Answer :
The isoelectric point (pI) of tyrosine, calculated based on its pKa values, is approximately 5.65. At this pH, tyrosine exists in its zwitterionic form, with no net charge.
The isoelectric point (pI) of an amino acid is the pH at which it carries no net electrical charge, as it exists in its zwitterionic form. To calculate the pI of tyrosine, we need to find the pH at which it is neutral, considering its ionizable groups.
Tyrosine has three ionizable groups with pKa values: carboxyl group (pKa ≈ 2.2), amino group (pKa ≈ 9.1), and the phenolic -OH group (pKa ≈ 10.1).
The pI is typically located between the two pKa values that surround the ionizable groups that can be protonated and deprotonated. In this case, the carboxyl group (pKa ≈ 2.2) and the amino group (pKa ≈ 9.1) are the relevant groups, so the pI of tyrosine would be around (2.2 + 9.1) / 2 ≈ 5.65.
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